Isolation of Anti-Prion Compounds from Curcuma phaeocaulis Valeton Extract

Author:

Kim Jaehyeon1,Lee Hakmin1,Kim Hye Mi1,Kim Ji Hoon1ORCID,Byun Sanghoon1,Lee Sungeun1ORCID,Kim Chul Young1ORCID,Ryou Chongsuk1ORCID

Affiliation:

1. Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University ERICA, Ansan 15588, Gyeonggi-do, Republic of Korea

Abstract

Prion diseases, known as a group of fatal neurodegenerative disorders caused by prions, remain incurable despite extensive research efforts. In a recent study, crude extract from Curcuma phaeocaulis Valeton (Cp) showed promising anti-prion efficacy in in vitro and in vivo models, prompting further investigation into their active compounds. We endeavored to identify the chemical constituents of the Cp extract and discover potential anti-prion agents. With the use of centrifugal partition chromatography (CPC), major constituents were isolated from the n-hexane (HX) fraction of the extract in a single step. Spectroscopic analysis confirmed the presence of curcumenone, curcumenol, and furanodienone. Subsequent efficacy testing in a cell culture model of prion disease identified curcumenol and furanodienone as active compounds. This study underscores the potential of natural products in the search for effective treatments against prion diseases.

Funder

National Research Foundation of Korea

Publisher

MDPI AG

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