Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells-Reference-Cited by-同舟云学术

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Published:2024-07-09 Issue:14 Volume:29 Page:3246
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mukusheva Gulim K.¹,Jalmakhanbetova Roza I.²^ORCID,Shaibek Altynay Zh.¹^ORCID,Nurmaganbetova Manshuk S.¹,Zhasymbekova Aigerym R.¹,Nurkenov Oralgazy A.³^ORCID,Akishina Ekaterina A.⁴^ORCID,Kolesnik Irina A.⁴,Dikusar Evgenij A.⁴,Terpinskaya Tatiana I.⁵^ORCID,Kulchitsky Vladimir A.⁵,Potkin Vladimir I.⁴,Pushkarchuk Alexander L.⁴^ORCID,Lyakhov Dmitry A.⁶,Michels Dominik L.⁶

Affiliation:

1. Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan

2. Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan

3. Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan

4. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus

5. Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus

6. Computer, Electrical and Mathematical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia

Abstract

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.

Funder

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan

Belarusian State Scientific Research Program “Convergence 2025”

National Academy of Sciences of Belarus

KAUST baseline funding

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/14/3246/pdf

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