The Role and Mechanism of Paeoniae Radix Alba in Tumor Therapy

Author:

Yang Yating1,Yuan Ling2ORCID,Wang Kaili1ORCID,Lu Doudou3ORCID,Meng Fandi4ORCID,Xu Duojie1ORCID,Li Weiqiang5,Nan Yi4

Affiliation:

1. Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, China

2. College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China

3. School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China

4. Key Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China

5. Department of Chinese Medical Gastrointestinal, The Affiliated TCM Hospital, Ningxia Medical University, Wuzhong 751100, China

Abstract

Tumors have a huge impact on human life and are now the main cause of disease-related deaths. The main means of treatment are surgery and radiotherapy, but they are more damaging to the organism and have a poor postoperative prognosis. Therefore, we urgently need safe and effective drugs to treat tumors. In recent years, Chinese herbal medicines have been widely used in tumor therapy as complementary and alternative therapies. Medicinal and edible herbs are popular and have become a hot topic of research, which not only have excellent pharmacological effects and activities, but also have almost no side effects. Therefore, as a typical medicine and food homology, some components of Paeoniae Radix Alba (PRA, called Baishao in China) have been shown to have good efficacy and safety against cancer. Numerous studies have also shown that Paeoniae Radix Alba and its active ingredients treat cancer through various pathways and are also one of the important components of many antitumor herbal compound formulas. In this paper, we reviewed the literature on the intervention of Paeoniae Radix Alba in tumors and its mechanism of action in recent years and found that there is a large amount of literature on its effect on total glucosides of paeony (TGP) and paeoniflorin (PF), as well as an in-depth discussion of the mechanism of action of Paeoniae Radix Alba and its main constituents, with a view to promote the clinical development and application of Paeoniae Radix Alba in the field of antitumor management.

Funder

Ningxia Key Research and Development Program

Ningxia Natural Science Foundation

High-level Key Discipline Construction Project of State Administration of Traditional Chinese Medicine

Publisher

MDPI AG

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