Affiliation:
1. School of Pharmacy, Xi’an Medical University, Xi’an 710021, China
2. School of Materials and Chemical Engineering, Xi’an Technological University, Xi’an 710032, China
Abstract
Constructed on the moiety of a lactam screw ring, a near-infrared fluorescent probe RCya for Pd2+ was designed under the PET mechanism and synthesized by incorporating 2,4-dihydroxybenzaldehyde as the recognition group. Dynamic detection of aqueous Pd2+ by the probe RCya could be accomplished through ion competition, linear response, fluorescence-pH/time stabilities, and other optical tests. Moreover, the high selectivity, low cytotoxicity, cell permeability, and lysosome accumulation properties of RCya enabled the imaging applications on solid-state RCya–PAN composite nanofibers and in living cells. The recognition mechanism of probe RCya toward Pd2+ was further studied through simulation calculation and MS analysis.
Funder
Natural Science Foundation of Shaanxi Provincial Department of Education
Shaanxi Natural Science Basic Research Project
Xi’an Science and Technology Plan Project
Xi’an Association for Science and Technology Project
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science