Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol-Reference-Cited by-同舟云学术

Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol

Published:2019-10-23 Issue:21 Volume:24 Page:3812
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Takenaga Naoko^ORCID,Shoji Toshitaka,Menjo Takayuki,Hirai Akiko,Ueda Shohei,Kikushima Kotaro,Hanasaki Tomonori^ORCID,Dohi Toshifumi^ORCID

Abstract

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.

Funder

Japan Society for the Promotion of Science

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/24/21/3812/pdf

Reference53 articles.

1. The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

2. Synthesis, Biological Activity, and SAR of Antimycobacterial 9-Aryl-, 9-Arylsulfonyl-, and 9-Benzyl-6-(2-furyl)purines

3. Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides

4. A sequential direct arylation/Suzuki–Miyaura cross-coupling transformation of unprotected 2′-deoxyadenosine affords a novel class of fluorescent analogues

5. Comprehensive Heterocyclic Chemistry;Shaw,1984

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HFIP in Organic Synthesis;Chemical Reviews;2022-07-17

2. Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N⁷-Substituted Purine Biaryls;Chemical and Pharmaceutical Bulletin;2021-09-01

3. Triazines, tetrazines, and fused ring polyaza systems;Progress in Heterocyclic Chemistry;2021

4. Modern Strategies for Heterocycle Synthesis;Molecules;2020-05-27