Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures-Reference-Cited by-同舟云学术

Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Published:2018-05-06 Issue:5 Volume:23 Page:1099
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Ota Yosuke,Kakizawa Taeko,Itoh Yukihiro,Suzuki Takayoshi^ORCID

Funder

Ministry of Education, Culture, Sports, Science and Technology

Core Research for Evolutional Science and Technology

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

http://www.mdpi.com/1420-3049/23/5/1099/pdf

Reference46 articles.

1. Histone methylation: a dynamic mark in health, disease and inheritance

2. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

3. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

4. p53 is regulated by the lysine demethylase LSD1

5. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

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