Synergistic Therapeutic Effects of D-Mannitol–Cerium–Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury-Reference-Cited by-同舟云学术

Synergistic Therapeutic Effects of D-Mannitol–Cerium–Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury

Published:2024-06-13 Issue:12 Volume:29 Page:2819
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Zhang Yusheng¹²^ORCID,Wang Hong²,Yang Ruiying³,Zhang Ying¹,Chen Yao²,Jiang Cuiping²,Li Xianyu¹

Affiliation:

1. Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China

2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China

3. Traditional Chinese Medicine College, China Pharmaceutical University, Nanjing, 211198, China

Abstract

Acute lung injury (ALI) remains a significant global health issue, necessitating novel therapeutic interventions. In our latest study, we pioneered the use of D-mannitol–cerium–quercetin/rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential treatment for ALI. The MCQ/R NPs, which integrate rutin and quercetin for their therapeutic potential and D-mannitol for its pulmonary targeting, displayed exceptional efficacy. By utilizing cerium ions for optimal nanoparticle assembly, the MCQ/R NPs demonstrated an average size of less than 160 nm. Impressively, these nanoparticles outperformed conventional treatments in both antioxidative capabilities and biocompatibility. Moreover, our in vivo studies on LPS-induced ALI mice showed a significant reduction in lung tissue inflammation. This groundbreaking research presents MCQ/R NPs as a promising new approach in ALI therapeutics.

Funder

Fundamental Research Funds for the Central Public Welfare Research Institutes

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/12/2819/pdf

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