New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius-Reference-Cited by-同舟云学术

New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius

Published:2023-03-23 Issue:7 Volume:28 Page:2903
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Chen Jih-Jung¹²^ORCID,Yang Chang-Syun¹,Chen Yu-Hui³,Chao Che-Yi⁴,Chen Yu-Chang⁵^ORCID,Kuo Yeuh-Hsiung³⁶⁷^ORCID

Affiliation:

1. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan

2. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan

3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404327, Taiwan

4. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan

5. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807377, Taiwan

6. Chinese Medicine Research Center, China Medical University, Taichung 404327, Taiwan

7. Department of Biotechnology, Asia University, Taichung 413305, Taiwan

Abstract

Three new triterpenoids—spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)—were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4–20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC50 values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.

Funder

Ministry of Science and Technology (MOST), Taiwan

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/7/2903/pdf

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