Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones-Reference-Cited by-同舟云学术

Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

Published:2023-02-27 Issue:5 Volume:28 Page:2206
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Shi Jianwei¹,Wang Zhichuan²,Teng Xiaoxu¹,Zhang Bing³,Sun Kai²^ORCID,Wang Xin²

Affiliation:

1. School of Chemistry and Chemical Engineering, Yangtze Normal University, Chongqing 408100, China

2. College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China

3. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

Abstract

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.

Funder

National Natural Science Foundation of China

Projects of Chongqing Education Board

Natural Science Foundation Project of Chongqing CSTC

Fuling Science and Technology Commission Project

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/5/2206/pdf

Reference57 articles.

1. Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds;Henkel;Angew. Chem. Int. Ed.,1999

2. Making Carbon-Nitrogen Bonds in Biological and Chemical Synthesis;Hili;Nat. Chem. Biol.,2006

3. A Graphical Journey of Innovative Organic Architectures that Have Improved Our Lives;McGrath;J. Chem. Educ.,2010

4. Synthesis, Antiplatelet Activity and Comparative Molecular Field Analysis of Substituted 2-Amino-4H-pyrido[1,2-a]pyrimidin-4-ones, Their Congeners and Isosteric Analogues;Roma;Bioorg. Med. Chem.,2000

5. MexAB-OprM Specific Efflux Pump Inhibitors in Pseudomonas Aeruginosa. Part 4: Addressing the Problem of Poor Stability Due to Photoisomerization of an Acrylic Acid Moiety;Nakayama;Bioorg. Med. Chem. Lett.,2004

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