Brief History, Preparation Method, and Biological Application of Mesoporous Silica Molecular Sieves: A Narrative Review

Author:

Li Qiuping123ORCID,Zhou You4

Affiliation:

1. School of Pharmacy, Fuzhou Medical College of Nanchang University, Fuzhou 344000, China

2. Key Laboratory of Chronic Diseases, Fuzhou Medical College of Nanchang University, Fuzhou 344000, China

3. Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344000, China

4. State Key Laboratory Base of Novel Functional Materials and Preparation Science, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China

Abstract

It has been more than 30 years since the first ordered mesoporous silica molecular sieve (MCM-41) was reported, but the enthusiasm for exploiting mesoporous silica is still growing due to its superior properties, such as its controllable morphology, excellent hosting capability, easy functionalization, and good biocompatibility. In this narrative review, the brief history of the discovery of mesoporous silica and several important mesoporous silica families are summarized. The development of mesoporous silica microspheres with nanoscale dimensions, hollow mesoporous silica microspheres, and dendritic mesoporous silica nanospheres is also described. Meanwhile, common synthesis methods for traditional mesoporous silica, mesoporous silica microspheres, and hollow mesoporous silica microspheres are discussed. Then, we introduce the biological applications of mesoporous silica in fields such as drug delivery, bioimaging, and biosensing. We hope this review will help people to understand the history of the development of mesoporous silica molecular sieves and become familiar with their synthesis methods and applications in biology.

Funder

Science and Technology Research Project of Jiangxi Provincial Department of Education

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Natural Science Foundation of Ningbo

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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