Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity-Reference-Cited by-同舟云学术

Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity

Published:2023-12-14 Issue:24 Volume:28 Page:8079
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Konkova Anna V.¹,Savina Iulia V.¹^ORCID,Evtushok Darya V.¹^ORCID,Pozmogova Tatiana N.¹^ORCID,Solomatina Maria V.²^ORCID,Nokhova Alina R.²^ORCID,Alekseev Alexander Y.²³^ORCID,Kuratieva Natalia V.¹^ORCID,Eltsov Ilia V.⁴^ORCID,Yanshole Vadim V.⁵⁶^ORCID,Shestopalov Aleksander M.²³,Ivanov Anton A.¹^ORCID,Shestopalov Michael A.¹^ORCID

Affiliation:

1. Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia

2. Research Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St, Novosibirsk 630117, Russia

3. Research Institute of Applied Ecology, Dagestan State University, 43a Gadzhiyeva St, Makhachkala 367000, Russia

4. Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia

5. International Tomography Center SB RAS, 3a Institutskaya Str., Novosibirsk 630090, Russia

6. Department of Physics, Novosibirsk State University, 1 Pirogova St., Novosibirsk 630090, Russia

Abstract

Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [Mo12O28(μ-L)8]4− (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [Mo2O4(C2O4)2(H2O)2]2− in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/24/8079/pdf

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