Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target-Reference-Cited by-同舟云学术

Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target

Published:2023-12-13 Issue:24 Volume:28 Page:8076
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Hervin Vincent¹,Roy Vincent¹^ORCID,Agrofoglio Luigi A.¹^ORCID

Affiliation:

1. ICOA UMR CNRS 7311, Université d’Orléans et CNRS, Rue de Chartres, 45067 Orléans, France

Abstract

The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway represents opportunities for the development of novel antibacterial agents. Among the enzymes involved, Mur ligases, described herein, and especially the amide ligases MurC-F are key targets for the discovery of multi-inhibitors, as they share common active sites and structural features.

Funder

EUROFERI program

CHemBio

Techsab

RTR Motivhealth

Labex programs SYNOR

IRON

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/24/8076/pdf

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