Stereoselective Solid-State Synthesis of Biologically Active Cyclobutane and Dicyclobutane Isomers via Conformation Blocking and Transference-Reference-Cited by-同舟云学术

Stereoselective Solid-State Synthesis of Biologically Active Cyclobutane and Dicyclobutane Isomers via Conformation Blocking and Transference

Published:2024-06-19 Issue:12 Volume:29 Page:2909
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Qin Zhen¹²,Gu Yunqiong³,Young Davidjames⁴^ORCID,Hu Feilong¹,Luo Zhirong⁵

Affiliation:

1. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China

2. College of Intelligent Metallurgy, Guangxi Modern Polytechnic College, Hechi 473000, China

3. School of Environment and Life Science, Nanning Normal University, Nanning 530001, China

4. Glasgow College UESTC, University of Electronic Science and Technology of China, Chengdu 611731, China

5. Guangxi Key Laboratory of Urban Water Environment, College of Chemistry & Environment Engineering, Baise University, Baise 533000, China

Abstract

Conformations in the solid state are typically fixed during crystallization. Transference of “frozen” C=C conformations in 3,5-bis((E)-2-(pyridin-4-yl)vinyl)methylbenzene (CH3-3,5-bpeb) by photodimerization selectively yielded cyclobutane and dicyclobutane isomers, one of which (Isomer 2) exhibited excellent in vitro anti-cancer activity towards T-24, 7402, MGC803, HepG-2, and HeLa cells.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi

Xiangsi Lake Young Scholars of Guangxi Minzu University

Project of Improving the Basic Scientific Research Ability of Young and Middle-aged Teachers in Guangxi

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/12/2909/pdf

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