One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions-Reference-Cited by-同舟云学术

One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions

Published:2019-02-08 Issue:3 Volume:24 Page:601
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Ma Xiaoming,Zhang Xiaofeng,Qiu Weiqi,Zhang Wensheng,Wan Bruce,Evans Jason,Zhang Wei^ORCID

Abstract

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

http://www.mdpi.com/1420-3049/24/3/601/pdf

Reference46 articles.

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4. Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

5. New and mild method for the synthesis of alprazolam and diazepam and computational study of their binding mode to GABAA receptor

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