Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology-Reference-Cited by-同舟云学术

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Published:2020-02-15 Issue:4 Volume:25 Page:857
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Yazdani Hossein,Kaul Esha,Bazgir Ayoob,Maysinger Dusica^ORCID,Kakkar Ashok

Abstract

An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/25/4/857/pdf

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