Affiliation:
1. State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China
Abstract
Vitamin C (VC), also known as ascorbic acid, plays a crucial role as a water-soluble nutrient within the human body, contributing to a variety of metabolic processes. Research findings suggest that increased doses of VC demonstrate potential anti-tumor capabilities. This review delves into the mechanisms of VC absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems for VC, evaluating its use in diverse cancer treatment methods. These include starvation therapy, chemodynamic therapy (CDT), photothermal/photodynamic therapy (PTT/PDT), electrothermal therapy, immunotherapy, cellular reprogramming, chemotherapy, radiotherapy, and various combination therapies.
Funder
Guangxi Science and Technology Major Program
National Nature Science Foundation of China
Reference107 articles.
1. Vitamin C content in fruits: Biosynthesis and regulation;Fenech;Front. Plant Sci.,2019
2. The biosynthetic pathway of vitamin C in higher plants;Wheeler;Nature,1998
3. Paciolla, C., Fortunato, S., Dipierro, N., Paradiso, A., De Leonardis, S., Mastropasqua, L., and De Pinto, M.C. (2019). Vitamin C in plants: From functions to biofortification. Antioxidants, 8.
4. Vitamin C in health and disease: Its role in the metabolism of cells and redox state in the brain;Front. Physiol.,2015
5. Nuclear and cytoplasmic functions of vitamin C;Zhitkovich;Chem. Res. Toxicol.,2020