Author:
Huang Xiao-Ling,Wang Dai-Wei,Liu Ying-Qian,Cheng Yong-Xian
Abstract
Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
Funder
National Key Research and Development Program of China
Shenzhen Fundamental Research Program
National Science Fund for Distinguished Young Scholars
Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Cited by
3 articles.
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