Abstract
An attempt was made to evaluate the possibility of creating and assessing the stability of inclusion complexes of selected phenolic acids [trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid)] with β-cyclodextrin and 2-HP-β-cyclodextrin in aqueous solutions in a wide temperature range 283.15 K–313.15 K. On the basis of the values of the limiting molar conductivity (ΛCDNaDod), calculated from the experimental data, the values of the formation constants and the thermodynamic functions of formation (standard enthalpy, entropy, and Gibs standard enthalpy) of the studied complexes were determined. It has been found that the stability of the studied complexes increases with lowering of the molar mass of cyclodextrin and lowering of the temperature.
Funder
Ministry of Science and Higher Education of the Republic of Poland
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference39 articles.
1. Introduction and general overview of cyclodextrin chemistry;Szetjli;Chem. Rev.,1998
2. Cyclodextrin properties and applications of inclusion complex formation;Martin;ARS Pharm.,1995
3. Cyclodextrin and their uses: A review;Process Biochem.,2004
4. Flour based foods containing highly branched cyclodextrins;Fujishima;Jpn. Pat. JP,2001
5. Approaches to reducing toxicity of parenteral anticancer drug formulations using cyclodextrins;Bhardway;J. Pharm. Sci. Technol.,2000
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献