Abstract
In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite Leishmania tarentolae. In a series of cell viability tests and enzyme assays, these test compounds have produced interesting results with regard to their antibiotic effect, showing similar potency against L. tarentolae as they do against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). All compounds tested in this study have shown the ability to completely inhibit our model system, L. tarentolae, in vitro. This study helps increase our understanding of the structure-activity relationship (SAR) between anaephene B and its analogues for a new class of potential pharmaceuticals for the treatment of Leishmania infections.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference18 articles.
1. Cell biology of Leishmania spp.: Invading and evading;Martiny;Curr. Pharm. Des.,2002
2. Centers for Disease Control and Prevention (CDC) (2020, October 17). About Leishmaniasis, Available online: https//www.cdc.gov/parasites/leishmaniasis/gen_info/faqs.html.
3. An analysis of FDA-approved drugs: Natural products and their derivatives;Patridge;Drug Discov. Today,2016
4. Structural characterization of naphthalene sulfonamides and a sulfonate ester and their in vitro efficacy against Leishmania tarentolae promastigotes;Li;New J. Chem.,2021
5. (2020, February 14). Centers for Disease Control and Prevention Parasites-Leishmaniasis. U.S. Department of Health & Human Services, Available online: www.cdc.gov/parasites/leishmaniasis/index.html.