Abstract
The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli, Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant.
Funder
European Regional Development Fund
Fundação para a Ciência e a Tecnologia
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference61 articles.
1. The curious characteristics of pyrazinamide: A review;Zhang;Int. J. Tuberc. Lung Dis.,2003
2. Iron enhances the antituberculous activity of pyrazinamide
3. Treatment of tuberculosis: Guidelines;Cavalcante,2010
4. https://apps.who.int/iris/bitstream/handle/10665/325771/WHO-MVP-EMP-IAU-2019.06-eng.pdf?ua=1
5. The chemotherapy of tuberculosis: past, present and future [State of the art]
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