Association between Age at Diagnosis of Type 2 Diabetes and Subsequent Risk of Dementia and Its Major Subtypes

Author:

Seo Da Hea1,Kim Mina2ORCID,Cho Yongin1ORCID,Ahn Seong Hee1,Hong Seongbin1,Kim So Hun1ORCID

Affiliation:

1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea

2. Department of Data Science, Hanmi Pharmaceutical Company Limited, Seoul 05545, Republic of Korea

Abstract

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major contributor to cognitive decline and dementia in older adults; however, the role of the age of onset of T2DM in younger patients remains uncertain. We explored the association between the risk of dementia and its subtypes in relation to the age at T2DM diagnosis. Methods: This population cohort study included a total of 612,201 newly diagnosed T2DM patients. The controls were randomly selected from the general population and matched at a 1:2 ratio based on the propensity score. The outcomes of interest were all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VD). The association of T2DM with dementia was stratified by the age at diagnosis of T2DM. Results: The mean ages of the subjects in the T2DM and control groups were 55.7 ± 13.0 and 55.7 ± 13.0. The patients with T2DM diagnosed at <50 years had the highest excess risk for most outcomes relative to the controls, with a hazard ratio (HR) (95% CI) of 3.29 (3.11–3.49) for all-cause dementia, 4.08 (3.18–5.24) for AD, and 5.82 (3.84–8.81) for VD. All risks were attenuated progressively with each increasing decade at the diagnostic age, but remained significant; for T2DM diagnosed at ≥80 years, the HR (95% CI) was 1.38 (1.34–1.41) for all-cause dementia, 1.35 (1.31–1.40) for AD, and 1.98 (1.70–2.30) for VD. Conclusions: We need to stratify T2DM management according to the age of diagnosis. Physicians should closely monitor cognitive function in patients with T2DM, especially in younger individuals.

Funder

INHA UNIVERSITY Research Grant

Publisher

MDPI AG

Reference31 articles.

1. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040;Ogurtsova;Diabetes Res. Clin. Pract.,2017

2. Centers for Disease Control and Prevention (2021, March 24). National Diabetes Statistics Report, 2020, Available online: https://www.cdc.gov/diabetes/library/features/diabetes-stat-report.html.

3. The characteristics of newly diagnosed adult early-onset diabetes: A population-based cross-sectional study;Zou;Sci. Rep.,2017

4. Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years;Matthews;Alzheimer’s Dement. J. Alzheimer’s Assoc.,2019

5. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission;Livingston;Lancet,2020

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