Antiviral and Antibacterial 3D-Printed Products Functionalised with Poly(hexamethylene biguanide)

Author:

Luk Anson M. Y.12ORCID,Lo Chris K. Y.1,Chiou Jiachi Amber3ORCID,Ngai Chi-Hang4,Law Ki2,Lau Tsz-Long2,Chen Wan-Xue1,Hui Matthew2ORCID,Kan Chi-Wai1ORCID

Affiliation:

1. School of Fashion and Textiles, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

2. Immune Materials Limited, Room 05, Unit 107-109, 1/F, 9 Science Park West Avenue, Hong Kong Science Park, Pak Shek Kok, N.T., Hong Kong SAR, China

3. Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

4. University Research Facility in 3D Printing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

Abstract

Infection prevention and public health are a vital concern worldwide, especially during pandemics such as COVID-19 and seasonal influenza. Frequent manual disinfection and use of chemical spray coatings at public facilities are the typical measures taken to protect people from coronaviruses and other pathogens. However, limitations of human resources and coating durability, as well as the safety of disinfectants used are the major concerns in society during a pandemic. Non-leachable antimicrobial agent poly(hexamethylene biguanide) (PHMB) was mixed into photocurable liquid resins to produce novel and tailor-made covers for public facilities via digital light processing, which is a popular 3D printing technique for satisfactory printing resolution. Potent efficacies of the 3D-printed plastics were achieved in standard antibacterial assessments against S. aureus, E. coli and K. pneumoniae. A total of 99.9% of Human coronavirus 229E was killed after being in contact with the 3D-printed samples (containing the promising PHMB formulation) for two hours. In an eight-week field test in Hong Kong Wetland Park, antibacterial performances of the specially designed 3D-printed covers analysed by environmental swabbing were also found to be satisfactory. With these remarkable outcomes, antimicrobial products prepared by digital light processing 3D printing can be regarded as a reliable solution to long-term infection prevention and control.

Funder

Hong Kong Innovation and Technology Fund

Hong Kong Polytechnic University

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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