Intranasal Ion-Triggered In Situ Delivery System of Virus-like Particles: Development Using the Quality by Design Approach
Author:
Bakhrushina Elena O.1ORCID, Mikhel Iosif B.1ORCID, Kondratieva Valeriya M.2, Zubareva Irina M.1, Kosenkova Svetlana I.1ORCID, Belyatskaya Anastasiya V.1, Stepanova Olga I.1, Krasnyuk Ivan I.1ORCID, Grebennikova Tatyana V.2ORCID, Krasnyuk Ivan I.1
Affiliation:
1. A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia 2. Departament of Epidemiology and Microbiology, The Gamaleya National Centre of Epidemiology and Microbiology, Moscow 123098, Russia
Abstract
The rapid growth in the prevalence of infectious diseases requires timely action from drug developers. In recent years, the COVID-19 pandemic has demonstrated the unpreparedness of the population for such emergencies. The introduction of modern methods of Design of Experiments (DoE) is required to accelerate the process of drug development and bring a drug to market. The main objective of this study was to develop an ion-triggered in situ system for intranasal delivery of VLP using a Quality by Design approach. Based on a literature review and initial studies, the key QTPP, CQA, CPP, and CMA were identified to develop a novel delivery system for virus-like particles. As a result of the studies on the quality attributes of the developed delivery system, an ion-triggered in situ gel meeting all the specified parameters was obtained using the Quality by Design method.
Reference40 articles.
1. Nagaraja, S., Basavarajappa, G.M., Karnati, R.K., Bakir, E.M., and Pund, S. (2021). Ion-Triggered in Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules. Pharmaceutics, 13. 2. Zhang, Y., Li, Q., Hu, J., Wang, C., Wan, D., Li, Q., Jiang, Q., Du, L., and Jin, Y. (2022). Nasal Delivery of Cinnarizine Thermo-and Ion-Sensitive In Situ Hydrogels for Treatment of Microwave-Induced Brain Injury. Gels, 8. 3. Teaima, M.H., Helal, D.A., Alsofany, J.M., El-Nabarawi, M.A., and Yasser, M. (2022). Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal. Pharmaceutics, 14. 4. Design of Intranasal Dosage Forms: Biopharmaceutical Aspects;Demina;Farmaciya (Pharmacy),2019 5. Prospects for the Use of Plant Polysaccharides in Complex Treatment of Malignant Tumors;Safonova;Eksperimental’naya i Klinicheskaya Farmakologiya,2012
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