New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites-Reference-Cited by-同舟云学术

New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites

Published:2023-12-29 Issue:1 Volume:16 Page:125
ISSN:2073-4360
Container-title:Polymers
language:en
Short-container-title:Polymers

Author:

Predoi Daniela¹,Ciobanu Steluta Carmen¹^ORCID,Iconaru Simona Liliana¹^ORCID,Ţălu Ştefan²^ORCID,Ghegoiu Liliana¹,Matos Robert Saraiva³^ORCID,da Fonseca Filho Henrique Duarte⁴^ORCID,Trusca Roxana⁵

Affiliation:

1. National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania

2. The Directorate of Research, Development and Innovation Management (DMCDI), Technical University of Cluj-Napoca, 15 Constantin Daicoviciu St., 400020 Cluj-Napoca, Romania

3. Amazonian Materials Group, Physics Department, Federal University of Amapá (UNIFAP), Macapá 68903-419, Amapá, Brazil

4. Laboratory of Synthesis of Nanomaterials and Nanoscopy (LSNN), Physics Department, Federal University of Amazonas-UFAM, Manaus 69067-005, Amazonas, Brazil

5. National Centre for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania

Abstract

The new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase formation. The element map scanning during the EDS analysis revealed homogenous distribution of constituent elements of calcium, phosphor, oxygen and magnesium. The presence of dextran in the sample was revealed by Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the 10MgHAPD nanocomposites was assessed by in vitro assays using Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Streptococcus mutans ATCC 25175, Porphyromonas gingivalis ATCC 33277 and Candida albicans ATCC 10231 microbial strains. The results of the antimicrobial assays highlighted that the 10MgHApD nanocomposites presented excellent antimicrobial activity against all the tested microorganisms and for all the tested time intervals. Furthermore, the biocompatibility assays determined that the 10MgHApD nanocomposites did not exhibit any toxicity towards Human gingival fibroblast (HGF-1) cells.

Funder

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii

Independent contract

Coordenação de Aperfeicoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Amazonas

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

Link

https://www.mdpi.com/2073-4360/16/1/125/pdf

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