Dysfunctional Heteroreceptor Complexes as Novel Targets for the Treatment of Major Depressive and Anxiety Disorders

Author:

Pérez de la Mora Miguel,Borroto-Escuela Dasiel O.ORCID,Crespo-Ramírez Minerva,Rejón-Orantes José del CarmenORCID,Palacios-Lagunas Daniel Alejandro,Martínez-Mata Magda K.,Sánchez-Luna Daniela,Tesoro-Cruz EmilianoORCID,Fuxe KjellORCID

Abstract

Among mental diseases, major depressive disorder (MDD) and anxiety deserve a special place due to their high prevalence and their negative impact both on society and patients suffering from these disorders. Consequently, the development of novel strategies designed to treat them quickly and efficiently, without or at least having limited side effects, is considered a highly important goal. Growing evidence indicates that emerging properties are developed on recognition, trafficking, and signaling of G-protein coupled receptors (GPCRs) upon their heteromerization with other types of GPCRs, receptor tyrosine kinases, and ionotropic receptors such as N-methyl-D-aspartate (NMDA) receptors. Therefore, to develop new treatments for MDD and anxiety, it will be important to identify the most vulnerable heteroreceptor complexes involved in MDD and anxiety. This review focuses on how GPCRs, especially serotonin, dopamine, galanin, and opioid heteroreceptor complexes, modulate synaptic and volume transmission in the limbic networks of the brain. We attempt to provide information showing how these emerging concepts can contribute to finding new ways to treat both MDD and anxiety disorders.

Funder

Dirección General de Asuntos del Personal Académico

Stiftelsen Olle Engkvist Byggmästare

Publisher

MDPI AG

Subject

General Medicine

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