Novel Hydrophilic Oligomer-Crosslinked Gelatin-Based Hydrogels for Biomedical Applications
Author:
Tariq Mamoona1, Khokhar Rabia23, Javed Arslan23ORCID, Usman Muhammad3ORCID, Anjum Syed Muhammad Muneeb3ORCID, Rasheed Huma3, Bukhari Nadeem Irfan2ORCID, Yan Chao1, Nawaz Hafiz Awais3
Affiliation:
1. School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Minhang District, Shanghai 200240, China 2. Punjab University College of Pharmacy (PUCP), University of the Punjab, Lahore 54000, Pakistan 3. Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences (UVAS), Lahore 54000, Pakistan
Abstract
Gelatin-based hydrogels have shown good injectability and biocompatibility and have been broadly used for drug delivery and tissue regeneration. However, their low mechanical strengths and fast degradation rates must be modified for long-term implantation applications. With an aim to develop mechanically stable hydrogels, reactive anhydride-based oligomers were developed and used to fabricate gelatin-based crosslinked hydrogels in this study. A cascade of hydrophilic oligomers containing reactive anhydride groups was synthesized by free radical polymerization. These oligomers varied in degree of reactivity, comonomer composition, and showed low molecular weights (Mn < 5 kDa). The reactive oligomers were utilized to fabricate hydrogels that differed in their mechanical strengths and degradation profiles. These formulations exhibited good cytocompatibility with human adipose tissue-derived stem cells (hADCs). In conclusion, the reactive MA-containing oligomers were successfully synthesized and utilized for the development of oligomer-crosslinked hydrogels. Such oligomer-crosslinked gelatin-based hydrogels hold promise as drug or cell carriers in various biomedical applications.
Funder
Higher Education Commission
Subject
Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering
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