Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Author:

Pistone Alessandro1ORCID,de Gaetano Annamaria1,Piperopoulos Elpida1ORCID,Abate Chiara1

Affiliation:

1. Department of Engineering, University of Messina, Contrada Di Dio, I-98166 Messina, Italy

Abstract

This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). The release of CUR from the CS-based particles with respect to time was analyzed, and the encapsulation efficiency and degree of swelling were studied. All formulations showed excellent CUR trapping efficiency, exceeding 90%. In particular, the TPP-crosslinked macrobeads released 34 wt% of the charged CUR within minutes, while the remaining 66 wt% was released slowly. The results indicate that the correct choice of gelling agent and its concentration leads to spherical particles capable of encapsulating CUR and releasing it in a wide range of kinetics so that macrospheres can be used in different applications.

Funder

NAVTEC (Research Consortium for Technological Innovation; naval, commercial and pleasure transport; Sicily, s.c.a.r.l), name of project: SIMARE—Innovative Solutions for High Energy Saving Vessels

Publisher

MDPI AG

Subject

General Materials Science

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