Nutritional Appraisal and Antidiabetic Activity of a Kind of Mixed Plasma Proteolytic Peptide from Tachpleus tridentatus

Abstract

Based on the bioactivities of blood protein, the nutritional appraisal and antidiabetic activity of a kind of mixed plasma proteolytic peptide from Tachpleus tridentatus (PPPT) were studied in this work. Results indicated that the amino acid level of PPPT could meet an adult’s FAO/WHO recommended standard; PPPT also manifested inhibitory activity on α-glucosidase with IC50 at 2.62 mg/mL in vitro, and relieved symptoms of type II diabetic mouse in vivo by improving glucose tolerance, increasing insulin secretion by 5.15 mIU/L in the PPPT-4 group and by 4.54 mIU/L in the PPPT-1 group, reducing blood glucose values to nearly normal levels 120 min after intragastric administration, and restoring pathological damage in the thymus. Thus, PPPT can be developed into both a healthcare product and an adjuvant for type II diabetes in the future.