Analyzing the Association between Candida Prevalence, Species Specificity, and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis— Candida and OSCC

Abstract

The present review is a qualitative and quantitative analysis of the overall prevalence of Candida, and its species specificity in oral squamous cell carcinoma (OSCC). PubMed, Scopus, and Web of Science databases were searched using the keywords ‘Candida and oral squamous cell carcinoma’. Only case-control observational studies in the English language evaluating the prevalence and species specificity of Candida in OSCC were included. 297 articles were identified (PubMed-106, Scopus-148, Web of Science-43) using the keywords. After screening the titles and abstracts, 206 articles were removed as they were duplicates (118) or irrelevant to the topic (88). Full text of the remaining 91 articles was assessed using the inclusion criteria, based on which only seven articles were included in the systematic review. For the quantitative analysis, the odds ratio and confidence interval were assessed and a forest plot was generated. Based on the meta-analysis, there is an association between the total Candida, Candida albicans (CA) and OSCC, while the association with non-Candida albicans (NCA) is relatively weak. The number of studies included in the meta-analysis was relatively low (four to five). Further, at least one of the studies included in the meta-analysis for the association of CA., NCA and total Candida with OSCC had a Newcastle–Ottawa score below 7. Thus, although the results showed an association, the quality and quantity of the evidence may not be sufficient for conclusive inference.