Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus

Author:

Bravo Victoria1,Serrano María2,Duque Alfonso3,Ferragud Juan4,Coronado Pluvio J.5ORCID

Affiliation:

1. Gynecology and Obstetrics Service, Hospital 12 de Octubre, 28041 Madrid, Spain

2. Gynecology and Obstetrics Service, Hospital la Paz, 28046 Madrid, Spain

3. Gynecology and Obstetrics Service, Hospital Ruber Internacional, 28034 Madrid, Spain

4. Medical Department, Atika Pharma, 35002 Las Palmas de Gran Canaria, Spain

5. Women’s Health Institute, San Carlos Clinical Hospital, dISSC, Complutense University, 28040 Madrid, Spain

Abstract

Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrrhizinic acid (Gly), the active ingredient in liquorice, has been shown in numerous preclinical studies to have an antiviral and anticancer activity, reducing the expression of E6 and E7 and inducing apoptosis in cervical cancer cells. In addition, it also has antioxidant, anti-inflammatory, immunomodulatory or re-epithelializing properties that can be useful in HPV infections. This review includes the different antiviral and anticancer mechanisms described for Gly, as well as the clinical studies carried out that position it as a potential therapeutic strategy against HPV both through its topical application and by oral administration.

Funder

Catalysis S.L.

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Reference46 articles.

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