New Derivatives of Lupeol and Their Biological Activity-Reference-Cited by-同舟云学术

New Derivatives of Lupeol and Their Biological Activity

Published:2021-12-10 Issue:4 Volume:2021 Page:M1306
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Le Hoang-Thuy-Tien,Chau Quoc-Cuong,Duong Thuc-Huy,Tran Quyen-Thien-Phuc,Pham Nguyen-Kim-Tuyen,Nguyen Thi-Hoai-Thu,Nguyen Ngoc-Hong,Sichaem Jirapast

Abstract

The natural product lupeol (1) was isolated from Bombax ceiba leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (2a, 2b, and 3) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds 3 showed significant α-glucosidase inhibition with an IC50 value of 202 µM, whereas 2a and 2b were inactive.

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2021/4/M1306/pdf

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