Cardiometabolic Profile, Physical Activity, and Quality of Life in Breast Cancer Survivors after Different Physical Exercise Protocols: A 34-Month Follow-Up Study
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Published:2023-07-20
Issue:14
Volume:12
Page:4795
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Bucciarelli Valentina12ORCID, Bianco Francesco12ORCID, Di Blasio Andrea3ORCID, Morano Teresa3, Tuosto Desiree2, Mucedola Francesco2, Di Santo Serena3, Cimini Alessandra4, Napolitano Giorgio3, Bucci Ines5, Di Baldassarre Angela3ORCID, Cianchetti Ettore4, Gallina Sabina2ORCID
Affiliation:
1. Cardiovascular Sciences Department—Azienda Ospedaliero-Universitaria delle Marche, 60126 Ancona, Italy 2. Department of Neurosciences, Imaging and Clinical Sciences, “G. d’Annunzio” University, 66100 Chieti, Italy 3. Department of Medicine and Aging Sciences, “G. d’Annunzio” University, 66100 Chieti, Italy 4. Eusoma Breast Centre, “G. Bernabeo” Hospital, ASL02 Lanciano-Vasto-Chieti, 66026 Ortona, Italy 5. Center for Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Abstract
Background: Breast cancer (BC) and cardiovascular (CV) disease share many risk factors associated with worse outcomes, in terms of cancer relapse, CV events, and quality of life (QoL), that could be counteracted by physical exercise (PE). We aimed to assess the impact of a 12-week differential PE protocol on cardiometabolic profile, QoL, CV- and BC-related long-term outcomes, and physical activity (PA) in a cohort of BC survivors (BCS) not treated with chemotherapy. Methods: 57 BCS participated in a 12-week PE protocol [aerobic exercise training (AET) or resistance exercise training (RET)]. Anthropometric and CV evaluation, health-related (HR)-QoL, daily PA, cortisol, and dehydroepiandrosterone sulfate (DHEA-S) levels were assessed before (T0) and after (T1) PE. We assessed BC and CV outcomes, HR-QoL, CV-QoL, and PA at the follow-up. Results: RET improved waist circumference, DHEA-S, cortisol/DHEA-S, systolic and mean blood pressure, and ventricular/arterial coupling; AET ameliorated sagittal abdomen diameter and pulse wave velocity. Regarding HR-QoL, physical function improved only in AET group. At a mean 34 ± 3.6-month follow-up, we documented no significant differences in CV-QoL, HR-QoL, and PA or CV and BC outcomes. Conclusions: AET and RET determine specific, positive adaptations on many parameters strongly related to CV risk, CV and BC outcomes, and QoL, and should be included in any cardio-oncology rehabilitation program.
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