1. Department of Cardiology, Freeman Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK
2. Translational Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
3. Academic Cardiovascular Unit, The James Cook University Hospital, Middlesbrough TS4 3BW, UK
4. Population Health Science Institute, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
5. Kancera AB, Karolinska Institutet Science Park, 171 65 Solna, Sweden
6. Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK