Parental Prepuberty Overweight and Offspring Lung Function

Author:

Lønnebotn MarianneORCID,Calciano LuciaORCID,Johannessen Ane,Jarvis Deborah L.,Abramson Michael J.ORCID,Benediktsdóttir Bryndís,Bråbäck Lennart,Franklin Karl A.,Godoy Raúl,Holm Mathias,Janson Christer,Jõgi Nils O.,Kirkeleit Jorunn,Malinovschi Andrei,Pereira-Vega AntonioORCID,Schlünssen ViviORCID,Dharmage Shyamali C.ORCID,Accordini SimoneORCID,Gómez Real Francisco,Svanes Cecilie

Abstract

In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents’ overweight on adult offspring’s lung function within the paternal and maternal lines. We included 929 offspring (aged 18–54, 54% daughters) of 308 fathers and 388 mothers (aged 40–66). Counterfactual-based multi-group mediation analyses by offspring’s sex (potential moderator) were used, with offspring’s prepubertal overweight and/or adult height as potential mediators. Unknown confounding was addressed by simulation analyses. Fathers’ overweight before puberty had a negative indirect effect, mediated through sons’ height, on sons’ forced expiratory volume in one second (FEV1) (beta (95% CI): −144 (−272, −23) mL) and forced vital capacity (FVC) (beta (95% CI): −210 (−380, −34) mL), and a negative direct effect on sons’ FVC (beta (95% CI): −262 (−501, −9) mL); statistically significant effects on FEV1/FVC were not observed. Mothers’ overweight before puberty had neither direct nor indirect effects on offspring’s lung function. Fathers’ overweight starting before puberty appears to cause lower FEV1 and FVC in their future sons. The effects were partly mediated through sons’ adult height but not through sons’ prepubertal overweight.

Funder

The Research Council of Norway

European Union Horizon 2020 research and innovation programme

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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