Serotype Distribution of Remaining Pneumococcal Meningitis in the Mature PCV10/13 Period: Findings from the PSERENADE Project
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Published:2021-04-01
Issue:4
Volume:9
Page:738
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ISSN:2076-2607
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Container-title:Microorganisms
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language:en
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Short-container-title:Microorganisms
Author:
Garcia Quesada MariaORCID, Yang Yangyupei, Bennett JuliaORCID, Hayford KylaORCID, Zeger Scott, Feikin Daniel, Peterson MeaganORCID, Cohen Adam, Almeida Samanta, Ampofo Krow, Ang Michelle, Bar-Zeev Naor, Bruce MichaelORCID, Camilli Romina, Chanto Chacón Grettel, Ciruela PilarORCID, Cohen CherylORCID, Corcoran MaryORCID, Dagan Ron, De Wals Philippe, Desmet Stefanie, Diawara IdrissaORCID, Gierke Ryan, Guevara MarcelaORCID, Hammitt Laura, Hilty Markus, Ho Pak-LeungORCID, Jayasinghe Sanjay, Kleynhans JackieORCID, Kristinsson Karl, Ladhani Shamez, McGeer Allison, Mwenda Jason, Nuorti J., Oishi Kazunori, Ricketson LeahORCID, Sanz Juan, Savrasova Larisa, Setchanova Lena, Smith AndrewORCID, Valentiner-Branth Palle, Valenzuela Maria, van der Linden Mark, van Sorge NinaORCID, Varon EmmanuelleORCID, Winje Brita, Yildirim Inci, Zintgraff Jonathan, Knoll MariaORCID,
Abstract
Pneumococcal conjugate vaccine (PCV) introduction has reduced pneumococcal meningitis incidence. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project described the serotype distribution of remaining pneumococcal meningitis in countries using PCV10/13 for least 5–7 years with primary series uptake above 70%. The distribution was estimated using a multinomial Dirichlet regression model, stratified by PCV product and age. In PCV10-using sites (N = 8; cases = 1141), PCV10 types caused 5% of cases <5 years of age and 15% among ≥5 years; the top serotypes were 19A, 6C, and 3, together causing 42% of cases <5 years and 37% ≥5 years. In PCV13-using sites (N = 32; cases = 4503), PCV13 types caused 14% in <5 and 26% in ≥5 years; 4% and 13%, respectively, were serotype 3. Among the top serotypes are five (15BC, 8, 12F, 10A, and 22F) included in higher-valency PCVs under evaluation. Other top serotypes (24F, 23B, and 23A) are not in any known investigational product. In countries with mature vaccination programs, the proportion of pneumococcal meningitis caused by vaccine-in-use serotypes is lower (≤26% across all ages) than pre-PCV (≥70% in children). Higher-valency PCVs under evaluation target over half of remaining pneumococcal meningitis cases, but questions remain regarding generalizability to the African meningitis belt where additional data are needed.
Funder
Bill and Melinda Gates Foundation
Subject
Virology,Microbiology (medical),Microbiology
Cited by
31 articles.
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