Abstract
Chronic active Epstein–Barr virus infection (CAEBV) is a disease where Epstein–Barr virus (EBV)-infected T- or NK-cells are activated and proliferate clonally. The symptoms of this dual-faced disease include systemic inflammation and multiple organ failures caused by the invasion of infected cells: inflammation and neoplasm. At present, the only effective treatment strategy to eradicate EBV-infected cells is allogeneic stem cell transplantation. Lately, the investigation into the disease’s pathogenic mechanism and pathophysiology has been advancing. In this review, I will evaluate the new definition in the 2017 WHO classification, present the advancements in the study of CAEBV, and unfold the future direction.
Funder
Japan Agency for Medical Research and Development
Subject
Virology,Microbiology (medical),Microbiology
Reference47 articles.
1. Extranodal NK/T-cell lymphoma, nasal type;Chan,2017
2. Aggressive NK-cell leukemia;Chan,2017
3. EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood;Quintanilla-Martinez,2017
4. Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification
5. The Chronic Mononucleosis Syndrome
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献