Variation in Human Milk Composition Is Related to Differences in Milk and Infant Fecal Microbial Communities

Author:

Pace Ryan M.ORCID,Williams Janet E.,Robertson Bianca,Lackey Kimberly A.,Meehan Courtney L.,Price William J.ORCID,Foster James A.,Sellen Daniel W.ORCID,Kamau-Mbuthia Elizabeth W.,Kamundia Egidioh W.,Mbugua Samwel,Moore Sophie E.,Prentice Andrew M.ORCID,Kita Debela G.,Kvist Linda J.,Otoo Gloria E.,Ruiz Lorena,Rodríguez Juan M.ORCID,Pareja Rossina G.,McGuire Mark A.,Bode Lars,McGuire Michelle K.ORCID

Abstract

Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.

Funder

National Science Foundation

Ministerio de Economía, Industria y Competitividad, Gobierno de España

European Commission

National Institutes of Health

Medela

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3