Response of Escherichia coli to Acid Stress: Mechanisms and Applications—A Narrative Review
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Published:2024-08-28
Issue:9
Volume:12
Page:1774
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ISSN:2076-2607
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Container-title:Microorganisms
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language:en
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Short-container-title:Microorganisms
Author:
Li Zepeng1, Huang Zhaosong1, Gu Pengfei1ORCID
Affiliation:
1. School of Biological Science and Technology, University of Jinan, Jinan 250022, China
Abstract
Change in pH in growth conditions is the primary stress for most neutralophilic bacteria, including model microorganism Escherichia coli. However, different survival capacities under acid stress in different bacteria are ubiquitous. Research on different acid-tolerance mechanisms in microorganisms is important for the field of combating harmful gut bacteria and promoting fermentation performance of industrial strains. Therefore, this study aimed to carry out a narrative review of acid-stress response mechanism of E. coli discovered so far, including six AR systems, cell membrane protection, and macromolecular repair. In addition, the application of acid-tolerant E. coli in industry was illustrated, such as production of industrial organic acid and developing bioprocessing for industrial wastes. Identifying these aspects will open the opportunity for discussing development aspects for subsequent research of acid-tolerant mechanisms and application in E. coli.
Funder
Key R&D Program of Shandong Province, China National Natural Science Foundation of China Dongying Major Science and Technology Innovation Project
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