Microbial Symphony: Navigating the Intricacies of the Human Oral Microbiome and Its Impact on Health

Author:

Bhandary Rahul1,Venugopalan Geethu1,Ramesh Amitha1,Tartaglia Guilia2,Singhal Ishita3ORCID,Khijmatgar Shahnawaz4ORCID

Affiliation:

1. Department of Periodontology, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangalore 575018, India

2. School of Medicine, European University of Madrid, 28670 Madrid, Spain

3. Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20129 Milan, Italy

4. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy

Abstract

This comprehensive review delves into the forefront of research on the human oral microbiome, exploring recent advancements that span microbial colonization, state-of-the-art detection methodologies, and the complex interplay involved in disease progression. Through an exhaustive analysis of the contemporary literature, we illuminate the dynamic orchestration of microbial communities within the oral cavity, underscoring their pivotal role in health and disease. Cutting-edge detection techniques, including metagenomics and high-throughput sequencing, are discussed regarding their transformative impact on understanding the intricacies of oral microbial ecosystems. As we stand on the cusp of a new decade, this review anticipates a paradigm shift in the field, emphasizing the potential for rapid identification and targeted management of detrimental oral microorganisms. Insights gained from this exploration not only contribute to our fundamental understanding of the oral microbiome but also hold promise for the development of innovative therapeutic strategies to maintain oral health. This article aims to serve as a valuable resource for researchers, clinicians, and public health professionals engaged in unraveling the mysteries of the microbial symphony within the human oral cavity.

Funder

Italian Ministry of Health, Current research IRCCS

Publisher

MDPI AG

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