Affiliation:
1. Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan’an University, Yan’an 716000, China
2. Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, Yan’an University, Yan’an 716000, China
Abstract
Previous investigations have illuminated the significant association between the gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, and psychiatric disorders. Evidence from certain studies suggests that dysbiosis of the gut microbiota may play a role in the etiology of obesity and diabetes. Moreover, it is acknowledged that dietary habits, pharmacological interventions, psychological stress, and other exogenous factors can substantially influence the gut microbial composition. For instance, a diet rich in fiber has been demonstrated to increase the population of beneficial bacteria, whereas the consumption of antibiotics can reduce these advantageous microbial communities. In light of the established correlation between the gut microbiome and various pathologies, strategically altering the gut microbial profile represents an emerging therapeutic approach. This can be accomplished through the administration of probiotics or prebiotics, which aim to refine the gut microbiota and, consequently, mitigate the manifestations of associated diseases. The present manuscript evaluates the recent literature on the relationship between gut microbiota and metabolic syndrome published over the past three years and anticipates future directions in this evolving field.
Funder
Yan’an University Qin Chuanyuan “Scientist + Engineer” team Special
Yan’an University transformation of Scientific and Technological achievements
National College Students Innovation and Entrepreneurship Training Program
Yan’an Science and Technology Bureau Key Science and Technology Research and Development Program
Yan’an University’s production cultivation project
Shaanxi Provincial Natural Science Basic Research Program
Reference69 articles.
1. Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body;Cristofori;Front. Immunol.,2021
2. Organoids and organs-on-chips: Insights into human gut-microbe interactions;Puschhof;Cell Host Microbe,2021
3. Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors;Barbalho;Diabetes/Metab. Res. Rev.,2022
4. Lemieux, I., and Després, J.P. (2020). Metabolic Syndrome: Past, Present and Future. Nutrients, 12.
5. Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., and Assi, H.I. (2022). Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int. J. Mol. Sci., 23.