The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization-Reference-Cited by-同舟云学术

The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization

Published:2024-08-09 Issue:8 Volume:12 Page:1626
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Di Pierro Francesco¹²³^ORCID,Zerbinati Nicola³,Cazzaniga Massimiliano²,Bertuccioli Alexander¹⁴^ORCID,Palazzi Chiara Maria¹,Cavecchia Ilaria¹⁵^ORCID,Matera Mariarosaria¹⁶^ORCID,Labrini Edoardo⁷,Sagheddu Valeria⁷,Soldi Sara⁷^ORCID

Affiliation:

1. Microbiota International Clinical Society, 10123 Torino, Italy

2. Scientific & Research Department, Velleja Research, 20125 Milano, Italy

3. Department of Medicine and Technological Innovation, University of Insubria, 21100 Varese, Italy

4. Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61122 Urbino, Italy

5. Microbiomic Department, Koelliker Hospital, 10134 Turin, Italy

6. Department of Paediatric Emergencies, Misericordia Hospital, 58100 Grosseto, Italy

7. AAT—Advanced Analytical Technologies, Fiorenzuola d’Arda, 29017 Piacenza, Italy

Abstract

Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular abfA and abfB, favor regular intestinal motility, thus counteracting constipation. By analyzing the gene expression and the proliferative response in the presence of arabinan of the probiotic B. longum W11, a strain previously validated as an anti-constipation probiotic, we have speculated that its response mechanism to arabinan can effectively explain its clinical action. Our approach could be used in the future to select probiotics endowed with arabinofuranosidase-related anti-constipation effects.

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-2607/12/8/1626/pdf

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