Molecular Approach for the Laboratory Diagnosis of Periprosthetic Joint Infections

Author:

Gatti GiuliaORCID,Taddei FrancescaORCID,Brandolini Martina,Mancini Andrea,Denicolò Agnese,Congestrì Francesco,Manera Martina,Arfilli Valentina,Battisti Arianna,Zannoli Silvia,Marino Maria Michela,Marzucco Anna,Morotti Manuela,Grumiro Laura,Scalcione Agata,Dirani Giorgio,Cricca Monica,Sambri VittorioORCID

Abstract

The incidence of total joint arthroplasty is increasing over time since the last decade and expected to be more than 4 million by 2030. As a consequence, the detection of infections associated with surgical interventions is increasing and prosthetic joint infections are representing both a clinically and economically challenging problem. Many pathogens, from bacteria to fungi, elicit the immune system response and produce a polymeric matrix, the biofilm, that serves as their protection. In the last years, the implementation of diagnostic methodologies reduced the error rate and the turn-around time: polymerase chain reaction, targeted or broad-spectrum, and next-generation sequencing have been introduced and they represent a robust approach nowadays that frees laboratories from the unique approach based on culture-based techniques.

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

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