Myo-D-inositol Trisphosphate Signalling in Oomycetes

Author:

Nair Indu Muraleedharan,Condon Emma,Prestwich Barbara Doyle,Mackrill John JamesORCID

Abstract

Oomycetes are pathogens of plants and animals, which cause billions of dollars of global losses to the agriculture, aquaculture and forestry sectors each year. These organisms superficially resemble fungi, with an archetype being Phytophthora infestans, the cause of late blight of tomatoes and potatoes. Comparison of the physiology of oomycetes with that of other organisms, such as plants and animals, may provide new routes to selectively combat these pathogens. In most eukaryotes, myo-inositol 1,4,5 trisphosphate is a key second messenger that links extracellular stimuli to increases in cytoplasmic Ca2+, to regulate cellular activities. In the work presented in this study, investigation of the molecular components of myo-inositol 1,4,5 trisphosphate signaling in oomycetes has unveiled similarities and differences with that in other eukaryotes. Most striking is that several oomycete species lack detectable phosphoinositide-selective phospholipase C homologues, the enzyme family that generates this second messenger, but still possess relatives of myo-inositol 1,4,5 trisphosphate-gated Ca2+-channels.

Funder

Science Foundation Ireland, Frontiers for the Future

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Reference93 articles.

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fatal attraction: How Phytophthora zoospores find their host;Seminars in Cell & Developmental Biology;2023-10

2. Non-inositol 1,4,5-trisphosphate (IP3) receptor IP3-binding proteins;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;2023-06

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