Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus—A Case Report and Literature Review

Author:

Santini Marija12,Ljubić Jelena3ORCID,Šoštar Nikola4,Vilibić-Čavlek Tatjana25ORCID,Bogdanić Maja5,Zakotnik Samo6ORCID,Avšič-Županc Tatjana6ORCID,Korva Miša6ORCID,Kurolt Ivan Christian7ORCID,Radmanić Leona8ORCID,Šimičić Petra8ORCID,Krznarić Juraj29,Gjurašin Branimir9,Kutleša Marko29,Višković Klaudija10,Balent Nataša Cetinić11,Žunec Renata12,Margeta Marić Ivana13,Ribarović Ana14,Židovec-Lepej Snjezana8ORCID

Affiliation:

1. Department for Infections in Immunocompromised Patients, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

2. School of Medicine, University of Zagreb, 10000 Zagreb, Croatia

3. Infectious Diseases Department, County Hospital Čakovec, 40000 Čakovec, Croatia

4. Emergency Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

5. Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia

6. Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia

7. Research Department, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

8. Department for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

9. Department of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

10. Department of Radiology and Ultrasound, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

11. Department of Clinical Microbiology, University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, 10000 Zagreb, Croatia

12. Tissue Typing Laboratory, University Hospital Zagreb, 10000 Zagreb, Croatia

13. County Hospital “Dr. Josip Benčević”, 35000 Slavonski Brod, Croatia

14. County Hospital Zadar, 23000 Zadar, Croatia

Abstract

In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The diagnosis was confirmed by serum RT-PCR and serology and corroborated by phylogenetic analysis and chemokine profiling. The patient was a 23-year-old male from Zagreb, Croatia, who had recently traveled throughout Europe. He presented with fever, headache, abdominal pain, and sudden onset of ARDS. Treatment involved high-flow nasal cannula oxygen therapy and glucocorticoids, which resulted in a full recovery. A systematic literature review identified 10 cases of hantavirus pulmonary syndrome (HPS) caused by PUUV in various European countries and Turkey between 2002 and 2023. The median age of patients was 53 years (range 24–73), and six of the patients were male. Most patients were treated in intensive care units, but none received antiviral therapy targeting PUUV. Eight patients survived hospitalization. The presented case highlights the importance of considering HPS in the differential diagnosis of ARDS, even in areas where HFRS is the dominant form of hantavirus infection.

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Reference46 articles.

1. Hantavirus in humans: A review of clinical aspects and management;Vial;Lancet Infect. Dis.,2023

2. Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis;Tariq;Infect. Chemother.,2022

3. Akram, S.M., Mangat, R., and Huang, B. (2023). StatPearls [Internet], StatPearls Publishing.

4. The problem of nephropathia epidemica Myhrman-Zetterholm in relation to acute interstitial ne-phritis;Radosevic;Acta Med. Scand.,1954

5. An epidemic of hemorrhagic fever with renal syndrome in Croatia in 1995;Kuzman;Lijec. Vjesn.,1997

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3