Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation

Author:

Iancu Mihaela Adela1ORCID,Profir Monica2,Roşu Oana Alexandra2,Ionescu Ruxandra Florentina34,Cretoiu Sanda Maria3ORCID,Gaspar Bogdan Severus56ORCID

Affiliation:

1. Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania

2. Department of Oncology, Elias University Emergency Hospital, 011461 Bucharest, Romania

3. Department of Morphological Sciences, Cell and Molecular Biology and Histology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania

4. Department of Cardiology I, “Dr. Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania

5. Surgery Clinic, Emergency Clinical Hospital, 014461 Bucharest, Romania

6. Department of Surgery, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania

Abstract

The gut microbiota represents a community of microorganisms (bacteria, fungi, archaea, viruses, and protozoa) that colonize the gut and are responsible for gut mucosal structural integrity and immune and metabolic homeostasis. The relationship between the gut microbiome and human health has been intensively researched in the past years. It is now widely recognized that gut microbial composition is highly responsible for the general health of the host. Among the diseases that have been linked to an altered gut microbial population are diarrheal illnesses and functional constipation. The capacity of probiotics to modulate the gut microbiome population, strengthen the intestinal barrier, and modulate the immune system together with their antioxidant properties have encouraged the research of probiotic therapy in many gastrointestinal afflictions. Dietary and lifestyle changes and the use of probiotics seem to play an important role in easing constipation and effectively alleviating diarrhea by suppressing the germs involved. This review aims to describe how probiotic bacteria and the use of specific strains could interfere and bring benefits as an associated treatment for diarrhea and constipation.

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Reference229 articles.

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4. (2023, August 12). Human Microbiome Project. Available online: https://hmpdacc.org.

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