Affiliation:
1. School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
2. Department of Synthetic Organic & Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Abstract
Patients with diabetes are known to be more susceptible to infections following the establishment of Staphylococcus aureus in their nasal passages and on their skin. The present study evaluated the effects of staphylococcal enterotoxin A (SEA) on the immune responses of spleen cells derived from diabetic mice, and examined the effects of polyphenols, catechins, and nobiletin on inflammation-related gene expression associated with the immune response. (−)-Epigallocatechin gallate (EGCG), possessing hydroxyl groups, interacted with SEA, whereas nobiletin, possessing methyl groups, did not interact with SEA. The exposure of spleen cells derived from diabetic mice to SEA enhanced the expression of interferon gamma, suppressor of cytokine signaling 1, signal transducer and activator of transcription 3, interferon-induced transmembrane protein 3, Janus kinase 2, and interferon regulatory factor 3, suggesting that SEA sensitivity is variable in the development of diabetes. Both EGCG and nobiletin changed the expression of genes related to SEA-induced inflammation in spleen cells, suggesting that they inhibit inflammation through different mechanisms. These results may lead to a better understanding of the SEA-induced inflammatory response during diabetogenesis, and the establishment of methods to control these effects with polyphenols.
Subject
Virology,Microbiology (medical),Microbiology
Reference42 articles.
1. Identification and characterization of a new staphylococcal enterotoxin-related putative toxin encoded by two kinds of plasmids;Omoe;Infect. Immun.,2003
2. Ono, H.K., Hirose, S., Narita, K., Sugiyama, M., Asano, K., Hu, D.L., and Nakane, A. (2019). Histamine release from intestinal mast cells induced by staphylococcal enterotoxin a (SEA) evokes vomiting reflex in common marmoset. PLoS Pathog., 15.
3. Synergistic activation of Src, ERK and STAT pathways in PBMCs for Staphylococcal enterotoxin A induced production of cytokines and chemokines;Liu;Asian Pacific J. Allergy Immunol.,2020
4. Principles of interleukin (IL)-6-type cytokine signalling and its regulation;Heinrich;Biochem. J.,2003
5. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: Prevention by rosiglitazone;Lagathu;Biochem. Biophys. Res. Commun.,2003
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