Gut Microbiota and Respiratory Infections: Insights from Mendelian Randomization

Author:

Huang Shengyu1ORCID,Li Jiaqi1,Zhu Zhihao1,Liu Xiaobin2,Shen Tuo2,Wang Yusong3,Ma Qimin2,Wang Xin1,Yang Guangping1,Guo Guanghua1,Zhu Feng23

Affiliation:

1. Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

2. Department of Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

3. ICU of Burn and Trauma, Changhai Hospital, Shanghai 200433, China

Abstract

The role of the gut microbiota in modulating the risk of respiratory infections has garnered increasing attention. However, conventional clinical trials have faced challenges in establishing the precise relationship between the two. In this study, we conducted a Mendelian randomization analysis with single nucleotide polymorphisms employed as instrumental variables to assess the causal links between the gut microbiota and respiratory infections. Two categories of bacteria, family Lactobacillaceae and genus Family XIII AD3011, were causally associated with the occurrence of upper respiratory tract infections (URTIs). Four categories of gut microbiota existed that were causally associated with lower respiratory tract infections (LRTIs), with order Bacillales and genus Paraprevotella showing a positive association and genus Alistipes and genus Ruminococcaceae UCG009 showing a negative association. The metabolites and metabolic pathways only played a role in the development of LRTIs, with the metabolite deoxycholine acting negatively and menaquinol 8 biosynthesis acting positively. The identification of specific bacterial populations, metabolites, and pathways may provide new clues for mechanism research concerning therapeutic interventions for respiratory infections. Future research should focus on elucidating the potential mechanisms regulating the gut microbiota and developing effective strategies to reduce the incidence of respiratory infections. These findings have the potential to significantly improve global respiratory health.

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

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