Phylogenetic Characterization of Rabies Virus Field Isolates Collected from Animals in European Russian Regions in 2009

Phylogenetic Characterization of Rabies Virus Field Isolates Collected from Animals in European Russian Regions in 2009–2022

Published:2023-10-10 Issue:10 Volume:11 Page:2526
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Chupin Sergei A.¹^ORCID,Sprygin Alexandr V.²^ORCID,Zinyakov Nikolay G.³^ORCID,Guseva Nelly A.³^ORCID,Shcherbinin Sergey V.⁴,Korennoy Fedor I.⁴^ORCID,Adelshin Renat V.⁵⁶^ORCID,Mazloum Ali²^ORCID,Sukharkov Andrey Y.¹,Nevzorova Victoria V.⁷

Affiliation:

1. Reference Laboratory for Rabies and BSE, Federal Centre for Animal Health, 600901 Vladimir, Russia

2. Laboratory of Molecular and Genetic Researches, Federal Centre for Animal Health, 600901 Vladimir, Russia

3. Reference Laboratory for Viral Avian Diseases, Federal Centre for Animal Health, 600901 Vladimir, Russia

4. Information Analysis Centre under the Department for Veterinary Surveillance, Federal Centre for Animal Health, 600901 Vladimir, Russia

5. Irkutsk Anti-Plague Research Institute of Siberia and the Far East, 664047 Irkutsk, Russia

6. Faculty of Biology and Soil Sciences, Irkutsk State University, 664033 Irkutsk, Russia

7. Belgorod Branch of the Federal Centre for Animal Health, 308015 Belgorod, Russia

Abstract

Rabies is a fatal disease of mammals that poses a high zoonotic risk to humans as well. The distribution of rabies is mainly driven by host animal migration and human-mediated dispersion. To contribute to the global understanding of the rabies virus (RABV) molecular epidemiology, 94 RABV field isolates collected from animals in 13 European Russian regions were phylogenetically characterized using the nearly full-size N gene nucleotide sequences. According to phylogenetic inferences, all isolates belonged to one of the two established phylogenetic groups, either group C (n = 54) or group D (n = 40), which are part of the clade Cosmopolitan of RABVs. Some representatives of group C collected from regions located far apart from each other had a remarkably high level of nucleotide identity. The possibility of the contribution of local bat species to the distribution of RABVs was discussed. Interestingly, over the years, the fraction of group D isolates has been constantly decreasing compared with that of group C isolates. The phylogenetic insights generated herein might have an important contribution to the control and surveillance of animal rabies epidemiology in the region.

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Link

https://www.mdpi.com/2076-2607/11/10/2526/pdf

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