Epigenetic Targets and Pathways Linked to SARS-CoV-2 Infection and Pathology-Reference-Cited by-同舟云学术

Epigenetic Targets and Pathways Linked to SARS-CoV-2 Infection and Pathology

Published:2023-01-30 Issue:2 Volume:11 Page:341
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Rabaan Ali A.¹²³^ORCID,Aljeldah Mohammed⁴^ORCID,Shammari Basim R. Al⁴^ORCID,Alsubki Roua A.⁵^ORCID,Alotaibi Jawaher⁶^ORCID,Alhashem Yousef N.⁷^ORCID,Alali Neda A.⁸,Sulaiman Tarek⁹,Alsalem Zainab¹⁰,Bajunaid Huda A.¹¹,Garout Mohammed¹²,Alsaffar Heba A.¹³,Almuthree Souad A.¹⁴,Hudhaiah Doha¹⁵,Alzaher Azhar M.¹⁶,Alshaikh Fatimah A.¹⁷,Alshengeti Amer¹⁸¹⁹^ORCID,Najim Mustafa A.²⁰,Farahat Ramadan Abdelmoez²¹^ORCID,Mohapatra Ranjan K.²²^ORCID

Affiliation:

1. Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia

2. College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia

3. Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan

4. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia

5. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia

6. Infectious Diseases Unit, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia

7. Clinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia

8. Pediatric Department, Security Force Hospital, Riyadh 13526, Saudi Arabia

9. Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia

10. Department of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

11. Makkah Specialized Laboratory, Fakeeh Care Group, Hadda 25321, Saudi Arabia

12. Department of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia

13. Department of Azizia Primary Health Care, Ministry of Health, Dammam 32211, Saudi Arabia

14. Department of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi Arabia

15. Microbiology Laboratory, King Fahad University Hospital, Al Khobar 34445, Saudi Arabia

16. Improvement of Operation Department, Qatif Health Network, Qatif 31911, Saudi Arabia

17. Infection Prevention and Control Department, Qatif Central Hospital, Qatif 32654, Saudi Arabia

18. Department of Pediatrics, College of Medicine, Taibah University, Al-Madinah 41491, Saudi Arabia

19. Department of Infection Prevention and Control, Prince Mohammad Bin Abdulaziz Hospital, National Guard Health Affairs, Al-Madinah 41491, Saudi Arabia

20. Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah 41411, Saudi Arabia

21. Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt

22. Department of Chemistry, Government College of Engineering, Keonjhar 758002, India

Abstract

The scale at which the SARS-CoV-2/COVID-19 pandemic has spread remains enormous. Provided the genetic makeup of the virus and humans is readily available, the quest for knowing the mechanism and epidemiology continues to prevail across the entire scientific community. Several aspects, including immunology, molecular biology, and host-pathogen interaction, are continuously being dug into for preparing the human race for future pandemics. The exact reasons for vast differences in symptoms, pathophysiological implications of COVID-infections, and mortality differences remain elusive. Hence, researchers are also looking beyond traditional genomics, proteomics, and transcriptomics approach, especially entrusting the environmental regulation of the genetic landscape of COVID–human interactions. In line with these questions lies a critical process called epigenetics. The epigenetic perturbations in both host and parasites are a matter of great interest to unravel the disparities in COVID-19 mortalities and pathology. This review provides a deeper insight into current research on the epigenetic landscape of SARS-CoV-2 infection in humans and potential targets for augmenting the ongoing investigation. It also explores the potential targets, pathways, and networks associated with the epigenetic regulation of processes involved in SARS-CoV-2 pathology.

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Link

https://www.mdpi.com/2076-2607/11/2/341/pdf

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