Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries
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Published:2022-12-22
Issue:1
Volume:11
Page:31
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ISSN:2076-2607
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Container-title:Microorganisms
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language:en
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Short-container-title:Microorganisms
Author:
Soundararajan Manonmani, Marincola Gabriella, Liong Olivia, Marciniak TessaORCID, Wencker Freya D. R.ORCID, Hofmann Franka, Schollenbruch Hannah, Kobusch IrisORCID, Linnemann Sabrina, Wolf Silver A., Helal Mustafa, Semmler TorstenORCID, Walther BirgitORCID, Schoen Christoph, Nyasinga JustinORCID, Revathi Gunturu, Boelhauve MarcORCID, Ziebuhr Wilma
Abstract
Non-aureus staphylococci (NAS) are ubiquitous bacteria in livestock-associated environments where they may act as reservoirs of antimicrobial resistance (AMR) genes for pathogens such as Staphylococcus aureus. Here, we tested whether housing conditions in pig farms could influence the overall AMR-NAS burden. Two hundred and forty porcine commensal and environmental NAS isolates from three different farm types (conventional, alternative, and organic) were tested for phenotypic antimicrobial susceptibility and subjected to whole genome sequencing. Genomic data were analysed regarding species identity and AMR gene carriage. Seventeen different NAS species were identified across all farm types. In contrast to conventional farms, no AMR genes were detectable towards methicillin, aminoglycosides, and phenicols in organic farms. Additionally, AMR genes to macrolides and tetracycline were rare among NAS in organic farms, while such genes were common in conventional husbandries. No differences in AMR detection existed between farm types regarding fosfomycin, lincosamides, fusidic acid, and heavy metal resistance gene presence. The combined data show that husbandry conditions influence the occurrence of resistant and multidrug-resistant bacteria in livestock, suggesting that changing husbandry practices may be an appropriate means of limiting the spread of AMR bacteria on farms.
Funder
German Research Council German Federal Ministry of Education and Research Open Access Publication Fund of the University of Wuerzburg
Subject
Virology,Microbiology (medical),Microbiology
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